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Research applications include investigations into NAD+ metabolism, mitochondrial function, and metabolic adaptation.

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Selenium: Tracing Another Essential Element of Ferroptotic Cell Death

PMID: 26236730 Published Research Highlights Discovery 1973 Tripeptide Identified in Human Serum Pickart and Thaler first identified the GHK sequence in human plasma, discovering a tripeptide that prolonged survival of normal liver cells and stimulated growth in cell culture models

Mechanistically, PCK2-K100la augments its kinase activity and competitively inhibits the Parkin-mediated polyubiquitination of 3-oxoacyl-ACP synthase (OXSM), thereby altering mitochondrial fatty acid synthesis and boosting oxidative phosphorylation and the TCA cycle

Jacka FN, Cherbuin N, Anstey KJ, Sachdev P, Butterworth P